Long Term Acid Suppressant Medications (ppi聮s): Concerns and Care Health Articles | April 12 Womens Dak Prescott Jersey , 2015

Maintenance antisecretory acid therapy (PPI’s) are used in many patients, particularly those with gastroesophageal reflux disease(GERD). With the long-term use of any medication, drug safety becomes an important issue. Acid (HCl) is normally secreted into the gastric lumen, where it serves to both digest dietary protein and maintain a sterile environment by



Maintenance antisecretory acid therapy (PPI’s) are used in many patients Womens Ezekiel Elliott Jersey , particularly those with gastroesophageal reflux disease(GERD). With the long-term use of any medication, drug safety becomes an important issue. Acid (HCl) is normally secreted into the gastric lumen, where it serves to both digest dietary protein and maintain a sterile environment by removing ingested bacterias. Proton pump inhibitors (PPIs) are strong acid suppressants, and thus long term usage has raised several issues which shall be discussed in this article.


The three main concerns regarding the long-term usage of proton pump inhibitors (PPIs) include :


Risk of infectious complications – including Pneumonias, Cl difficile diarrhoeas


Malabsorption of Iron Womens Emmitt Smith Jersey , Vitamin B12, Magnesium and Metabolic bone disease


Hypergastrinemia, Gastric carcinoids and Atrophic Gastritis


Other concerns include acute interstitial nephritis (kidney disease) and drug interactions particularly reducing the effect of Clopidogrel, which is used in coronary stented patients to reduce the risk of stent blockage.


Infections
A concern with any form of gastric acid inhibition is an increased risk of enteric infections since gastric acid normally protects against these infections. In addition, a reduction in gastric acid secretion permits bacteria to more easily colonize the upper gastrointestinal tract Tony Pollard Jersey , which may predispose to pneumonia.


Clostridium difficile and other enteric infections
The best documented association of PPI use with enteric infections has been with C. difficile diarrhea, even in patients not exposed to antibiotics(1-7). C. difficile is an anaerobic organism that sporulates; acid-resistant spores are presumed to be the major vector of disease transmission. Three meta-analyses of observational studies have demonstrated an increas Wholesale NFL Jerseys